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1. Caldwell, D. (1999). Review of mononuclear cell leukemia (MNCL) in
F-344 rat bioassays and its significance to human cancer risk: A case study using alkyl phthalates.
Regulatory Toxicology and Pharmacology 30:45-53.
This paper reviewed data on MNCL and concluded that it is not relevant to humans.
2. Doull, J., Cattley, R., Elcombe, C., Lake, B., Swenberg, J., Wilkinson, C., Williams, G., and van Gemart, M. (1999). A cancer risk assessment of
di(2-ethylhexyl) phthalate: Application of the new U.S. EPA risk assessment guidelines.
Regulatory Toxicology and Pharmacology 29:327-357.
This paper evaluates the DEHP data against the draft EPA guidelines for carcinogen classification and concludes that DEHP-induced rodent liver tumors are not relevant to humans.
Last Updated: July 10, 2002
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